Package: admixr2
Type: Package
Title: Aggregate Data Modelling
Version: 0.4.1
Authors@R: c(
        person("H.", "van de Beek", email = "h.van.de.beek@lacdr.leidenuniv.nl", role = c("aut", "cre")),
        person("P.A.J.", "Välitalo", role = "aut"),
        person("L.B.", "Zwep", role = "aut"),
        person("J.G.C.", "van Hasselt", role = "aut")
    )
Description: Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data (mean vector
    and covariance matrix per study) rather than individual-level data, for meta-analysis
    across studies. Integrates
    with the 'nlmixr2'/'rxode2' ecosystem via four estimation methods: a First-Order ('FO')
    analytical estimator, a Monte Carlo (MC) estimator, a Gauss-Hermite quadrature ('GH')
    estimator, and an Iterative Reweighting Monte Carlo ('IRMC') estimator. Methods are
    based on Välitalo (2021) <doi:10.1007/s10928-021-09760-1>; software described in
    van de Beek et al. (2025) <doi:10.1007/s10928-025-10011-w>.
License: GPL (>= 3)
URL: https://leidenpharmacology.github.io/admixr2/,
        https://github.com/LeidenPharmacology/admixr2
BugReports: https://github.com/LeidenPharmacology/admixr2/issues
Encoding: UTF-8
LazyData: true
Depends: R (>= 4.1.0)
Imports: checkmate, digest, nlmixr2est (>= 6.0.1), nloptr, randtoolbox,
        Rcpp, rxode2 (>= 5.1.2), symengine
LinkingTo: Rcpp, RcppEigen
Suggests: expm, ggplot2, knitr, lotri, MASS, memuse, mirai, mnormt,
        nlmixr2 (>= 5.0.0), nlmixr2data, numDeriv, patchwork,
        rmarkdown, testthat (>= 3.0.0)
VignetteBuilder: knitr
Config/testthat/edition: 3
Config/testthat/parallel: true
Config/roxygen2/version: 8.0.0
NeedsCompilation: yes
Packaged: 2026-09-16 06:12:18 UTC; hidde
Author: H. van de Beek [aut, cre],
  P.A.J. Välitalo [aut],
  L.B. Zwep [aut],
  J.G.C. van Hasselt [aut]
Maintainer: H. van de Beek <h.van.de.beek@lacdr.leidenuniv.nl>
Repository: CRAN
Date/Publication: 2026-09-16 07:10:08 UTC
Built: R 4.5.2; x86_64-apple-darwin20; 2026-09-16 08:10:15 UTC; unix
Archs: admixr2.so.dSYM
