Package: precautionary
Type: Package
Title: Safety Diagnostics for Dose-Escalation Trial Designs
Version: 0.2.6
Date: 2021-08-01
Authors@R: c(person("David C.", "Norris"
                   , role = c("aut", "cre", "cph")
                   , email = "david@precisionmethods.guru"
                   , comment = c(ORCID = "0000-0001-9593-6343")
                   ),
             person("Markus", "Triska"
                   , role = "ctb"
                   , email = "triska@metalevel.at"
                   )
            )
Maintainer: David C. Norris <david@precisionmethods.guru>
Depends: magrittr, escalation, data.table, R6, R (>= 4.0.0)
Imports: methods, dplyr, rlang, stringr, knitr, kableExtra,
        microbenchmark, dfcrm, BOIN, parallelly
Suggests: dtpcrm, rmarkdown, bookdown, tufte, testthat, lattice,
        latticeExtra, shiny, shinyjs, shinyFeedback
Description: Enhances various R packages that support the design and simulation
             of phase 1 dose-escalation trials, adding diagnostics to examine
             the safety characteristics of these designs in light of expected
             inter-individual variation in pharmacokinetics and pharmacodynamics.
             See Norris (2020b), "Retrospective analysis of a fatal dose-finding
             trial" <arXiv:2004.12755> and (2020c) "What Were They Thinking?
             Pharmacologic priors implicit in a choice of 3+3 dose-escalation design"
             <arXiv:2012.05301>.
URL: https://github.com/dcnorris/precautionary
License: MIT + file LICENSE
VignetteBuilder: knitr, rmarkdown
Encoding: UTF-8
NeedsCompilation: yes
OS_type: unix
RoxygenNote: 7.1.1
Collate: 'bench.R' 'boin.R' 'ccd.R' 'cpe.R' 'crm.R' 'data.R' 'dtp.R'
        'dutycycle.R' 'enhance.R' 'exact.R' 'extendr-wrappers.R'
        'hyperprior.R' 'mclapply.R' 'precautionary-package.R'
        'toxicity_generators.R' 'simulate_trials.R' 'three3.R'
LazyData: true
ByteCompile: true
Config/testthat/edition: 3
BugReports: https://github.com/dcnorris/precautionary/issues
Packaged: 2021-08-07 12:12:16 UTC; david
Author: David C. Norris [aut, cre, cph]
    (<https://orcid.org/0000-0001-9593-6343>),
  Markus Triska [ctb]
Repository: CRAN
Date/Publication: 2021-08-09 08:00:02 UTC
